5JVT

Crystal structure of the DNA binding domain of transcription factor FLI1 in complex with an 11-mer DNA GACCGGAAGTG

Summary for 5JVT

• Entry DOI: 10.2210/pdb5jvt/pdb
• Related: 5JVW 5JW0 5JW2
• Descriptor: Friend leukemia integration 1 transcription factor, DNA (5'-D(*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*C)-3'), ... (6 entities in total)
• Functional Keywords: transcription, dna binding, cancer, ewing sarcoma, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q01543
• Total number of polymer chains: 9
• Total formula weight: 56608.22

Authors

Hou, C.,Tsodikov, O.V. (deposition date: 2016-05-11, release date: 2016-09-14, Last modification date: 2023-09-27)

• Primary citation: Hou, C.,Weidenbach, S.,Cano, K.E.,Wang, Z.,Mitra, P.,Ivanov, D.N.,Rohr, J.,Tsodikov, O.V.; Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.; Nucleic Acids Res., 44:8990-9004, 2016; PubMed: 27587584; DOI: 10.1093/nar/gkw761

Experimental method

X-RAY DIFFRACTION (3.1 Å)