5JPV

Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactoseamine mimic

Summary for 5JPV

• Entry DOI: 10.2210/pdb5jpv/pdb
• Related PRD ID: PRD_900008
• Descriptor: Asialoglycoprotein receptor 1, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: asialoglycoprotein receptor, carbohydrates, liver targeting, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform H1a: Membrane; Single-pass type II membrane protein. Isoform H1b: Secreted : P07306
• Total number of polymer chains: 2
• Total formula weight: 34983.65

Authors

Liu, S. (deposition date: 2016-05-04, release date: 2017-06-14, Last modification date: 2023-09-27)

• Primary citation: Sanhueza, C.A.,Baksh, M.M.,Thuma, B.,Roy, M.D.,Dutta, S.,Preville, C.,Chrunyk, B.A.,Beaumont, K.,Dullea, R.,Ammirati, M.,Liu, S.,Gebhard, D.,Finley, J.E.,Salatto, C.T.,King-Ahmad, A.,Stock, I.,Atkinson, K.,Reidich, B.,Lin, W.,Kumar, R.,Tu, M.,Menhaji-Klotz, E.,Price, D.A.,Liras, S.,Finn, M.G.,Mascitti, V.; Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.; J. Am. Chem. Soc., 139:3528-3536, 2017; PubMed: 28230359; DOI: 10.1021/jacs.6b12964

Experimental method

X-RAY DIFFRACTION (1.9 Å)