6UZU

Carbonic Anhydrase IX-mimic In Complex WITH U-CH3

Replaces:  5JN1

Summary for 6UZU

• Entry DOI: 10.2210/pdb6uzu/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, 4-{[(3,5-dimethylphenyl)carbamoyl]amino}benzene-1-sulfonamide, ... (5 entities in total)
• Functional Keywords: caix inhibitors, ph regulation, cancer therapeutics, transmembrane, lyase-lyase inhibitor complex, lyase, lyase/lyase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29385.52

Authors

McKenna, R.,Mboge, M.Y.,Mahon, B.P. (deposition date: 2019-11-15, release date: 2020-10-21, Last modification date: 2023-10-11)

• Primary citation: Mboge, M.Y.,Mahon, B.P.,Lamas, N.,Socorro, L.,Carta, F.,Supuran, C.T.,Frost, S.C.,McKenna, R.; Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.; Eur J Med Chem, 132:184-191, 2017; DOI: 10.1016/j.ejmech.2017.03.026

Experimental method

X-RAY DIFFRACTION (1.5 Å)