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5JG0

Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH and UCP1191

Summary for 5JG0
Entry DOI10.2210/pdb5jg0/pdb
DescriptorDihydrofolate reductase, 4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}benzoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordsoxidoreductase, dihydrofolate reductase, nadph, zwitterion, antibiotics
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total formula weight19189.42
Authors
Anderson, A.C.,Reeve, S.M. (deposition date: 2016-04-19, release date: 2017-04-19, Last modification date: 2024-03-06)
Primary citationReeve, S.M.,Scocchera, E.W.,G-Dayanadan, N.,Keshipeddy, S.,Krucinska, J.,Hajian, B.,Ferreira, J.,Nailor, M.,Aeschlimann, J.,Wright, D.L.,Anderson, A.C.
MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.
Cell Chem Biol, 23:1458-1467, 2016
Cited by
PubMed: 27939900
DOI: 10.1016/j.chembiol.2016.11.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.879 Å)
Structure validation

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