5JFS

Crystal structure of TrkA in complex with PF-00593174

Summary for 5JFS

Entry DOI	10.2210/pdb5jfs/pdb
Related	5JFV 5JFW 5JFX
Descriptor	High affinity nerve growth factor receptor, N-{4-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-N'-(2,4-difluorophenyl)urea (3 entities in total)
Functional Keywords	trka inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P04629
Total number of polymer chains	1
Total formula weight	35552.98
Authors	Jayasankar, J.,Brown, D.,Skerratt, S.,Kurumbail, R. (deposition date: 2016-04-19, release date: 2017-03-01, Last modification date: 2024-03-06)
Primary citation	Skerratt, S.E.,Andrews, M.,Bagal, S.K.,Bilsland, J.,Brown, D.,Bungay, P.J.,Cole, S.,Gibson, K.R.,Jones, R.,Morao, I.,Nedderman, A.,Omoto, K.,Robinson, C.,Ryckmans, T.,Skinner, K.,Stupple, P.,Waldron, G. The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. J. Med. Chem., 59:10084-10099, 2016 Cited by PubMed: 27766865 DOI: 10.1021/acs.jmedchem.6b00850 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation