5JEC

Apo-structure of humanised RadA-mutant humRadA33F

Summary for 5JEC

Entry DOI	10.2210/pdb5jec/pdb
Descriptor	DNA repair and recombination protein RadA, CHLORIDE ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	dna repair, fragment based drug design, humanisation, hydrolase
Biological source	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Total number of polymer chains	2
Total formula weight	50742.63
Authors	Fischer, G.,Marsh, M.,Moschetti, T.,Sharpe, T.,Scott, D.,Morgan, M.,Ng, H.,Skidmore, J.,Venkitaraman, A.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2016-04-18, release date: 2016-10-19, Last modification date: 2024-02-07)
Primary citation	Moschetti, T.,Sharpe, T.,Fischer, G.,Marsh, M.E.,Ng, H.K.,Morgan, M.,Scott, D.E.,Blundell, T.L.,R Venkitaraman, A.,Skidmore, J.,Abell, C.,Hyvonen, M. Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428:4589-4607, 2016 Cited by PubMed: 27725183 DOI: 10.1016/j.jmb.2016.10.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation