5JDC
Trypanosoma brucei PTR1 in complex with inhibitor NP-13 (Hesperetin)
Summary for 5JDC
Entry DOI | 10.2210/pdb5jdc/pdb |
Descriptor | Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one, ... (7 entities in total) |
Functional Keywords | trypanosoma brucei, pteridine reductase, oxydoreductase, inhibitor, oxidoreductase |
Biological source | Trypanosoma brucei brucei More |
Total number of polymer chains | 4 |
Total formula weight | 127184.07 |
Authors | Mangani, S.,Pozzi, C.,Di Pisa, F.,Landi, G.,Dello Iacono, L. (deposition date: 2016-04-16, release date: 2016-08-17, Last modification date: 2024-01-10) |
Primary citation | Borsari, C.,Luciani, R.,Pozzi, C.,Poehner, I.,Henrich, S.,Trande, M.,Cordeiro-da-Silva, A.,Santarem, N.,Baptista, C.,Tait, A.,Di Pisa, F.,Dello Iacono, L.,Landi, G.,Gul, S.,Wolf, M.,Kuzikov, M.,Ellinger, B.,Reinshagen, J.,Witt, G.,Gribbon, P.,Kohler, M.,Keminer, O.,Behrens, B.,Costantino, L.,Tejera Nevado, P.,Bifeld, E.,Eick, J.,Clos, J.,Torrado, J.,Jimenez-Anton, M.D.,Corral, M.J.,Alunda, J.M.,Pellati, F.,Wade, R.C.,Ferrari, S.,Mangani, S.,Costi, M.P. Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs. J.Med.Chem., 59:7598-7616, 2016 Cited by PubMed: 27411733DOI: 10.1021/acs.jmedchem.6b00698 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
Download full validation report