5J8A

Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline

This is a non-PDB format compatible entry.

Summary for 5J8A

• Entry DOI: 10.2210/pdb5j8a/pdb
• Related: 5IT8 5J5B 5J7L 5J88 5J91 5JC9
• Descriptor: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (70 entities in total)
• Functional Keywords: ribosome, resistance, negamycin, tigecycline, tetracycline, ribosome-antibiotic complex, ribosome/antibiotic
• Biological source: Escherichia coli; More
• Total number of polymer chains: 105
• Total formula weight: 4274600.14

Authors

Cocozaki, A.,Ferguson, A. (deposition date: 2016-04-07, release date: 2016-07-06, Last modification date: 2016-08-03)

• Primary citation: Cocozaki, A.I.,Altman, R.B.,Huang, J.,Buurman, E.T.,Kazmirski, S.L.,Doig, P.,Prince, D.B.,Blanchard, S.C.,Cate, J.H.,Ferguson, A.D.; Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.; Proc.Natl.Acad.Sci.USA, 113:8188-8193, 2016; PubMed: 27382179; DOI: 10.1073/pnas.1605127113

Experimental method

X-RAY DIFFRACTION (3.1 Å)