5J7W

Enterococcus faecalis thymidylate synthase complex with methotrexate

Summary for 5J7W

• Entry DOI: 10.2210/pdb5j7w/pdb
• Descriptor: Thymidylate synthase, SULFATE ION, METHOTREXATE, ... (4 entities in total)
• Functional Keywords: enterococcus faecalis, thymidylate synthase, methotrexate, complex, transferase
• Biological source: Enterococcus faecalis
• Cellular location: Cytoplasm : Q834R3
• Total number of polymer chains: 4
• Total formula weight: 146837.04

Authors

Mangani, S.,Pozzi, C. (deposition date: 2016-04-07, release date: 2016-09-28)

• Primary citation: Catalano, A.,Luciani, R.,Carocci, A.,Cortesi, D.,Pozzi, C.,Borsari, C.,Ferrari, S.,Mangani, S.; X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.; Eur.J.Med.Chem., 123:649-664, 2016; PubMed: 27517810; DOI: 10.1016/j.ejmech.2016.07.066

Experimental method

X-RAY DIFFRACTION (2.5 Å)