5IU4

Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with ZM241385 at 1.7A resolution

Summary for 5IU4

• Entry DOI: 10.2210/pdb5iu4/pdb
• Descriptor: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... (8 entities in total)
• Functional Keywords: g-protein-coupled receptor, integral membrane protein, chimera, thermostabilizing mutations, membrane protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P29274
• Total number of polymer chains: 1
• Total formula weight: 57335.61

Authors

Segala, E.,Guo, D.,Cheng, R.K.Y.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,Ijzerman, A.P.,Marshall, F.H.,Cooke, R.M. (deposition date: 2016-03-17, release date: 2016-06-29, Last modification date: 2024-01-10)

• Primary citation: Segala, E.,Guo, D.,Cheng, R.K.,Bortolato, A.,Deflorian, F.,Dore, A.S.,Errey, J.C.,Heitman, L.H.,IJzerman, A.P.,Marshall, F.H.,Cooke, R.M.; Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.; J.Med.Chem., 59:6470-6479, 2016; PubMed: 27312113; DOI: 10.1021/acs.jmedchem.6b00653

Experimental method

X-RAY DIFFRACTION (1.72 Å)