5IPK

Structure of the R432A variant of Adeno-associated virus type 2 VLP

This is a non-PDB format compatible entry.

Summary for 5IPK

• Entry DOI: 10.2210/pdb5ipk/pdb
• Related: 5IPI
• EMDB information: 8099 8100
• Descriptor: Capsid protein VP1 (1 entity in total)
• Functional Keywords: adeno-associated virus, r432a, gene therapy, icosahedral, dependoparvovirus, virus like particle
• Biological source: Adeno-associated virus - 2 (AAV-2)
• Total number of polymer chains: 60
• Total formula weight: 4916714.04

Authors

Drouin, L.M.,Lins, B.,Janssen, M.E.,Bennet, A.,Chipman, P.,McKenna, R.,Chen, W.,Muzyczka, N.,Cardone, G.,Baker, T.S.,Agbandje-McKenna, M. (deposition date: 2016-03-09, release date: 2016-07-20, Last modification date: 2024-03-06)

• Primary citation: Drouin, L.M.,Lins, B.,Janssen, M.,Bennett, A.,Chipman, P.,McKenna, R.,Chen, W.,Muzyczka, N.,Cardone, G.,Baker, T.S.,Agbandje-McKenna, M.; Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.; J.Virol., 90:8542-8551, 2016; PubMed: 27440903; DOI: 10.1128/JVI.00575-16

Experimental method

ELECTRON MICROSCOPY (3.7 Å)