5IJ8

Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor

Summary for 5IJ8

• Entry DOI: 10.2210/pdb5ij8/pdb
• Related: 5IJ7
• Descriptor: Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... (5 entities in total)
• Functional Keywords: lysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Anolis carolinensis (Green anole); More
• Cellular location: Nucleus : Q15910 O75530 Q15022
• Total number of polymer chains: 6
• Total formula weight: 275864.01

Authors

Gajiwala, K.S.,Brooun, A.,Deng, Y.-L.,Liu, W. (deposition date: 2016-03-01, release date: 2016-05-04, Last modification date: 2024-03-06)

• Primary citation: Brooun, A.,Gajiwala, K.S.,Deng, Y.L.,Liu, W.,Bolanos, B.,Bingham, P.,He, Y.A.,Diehl, W.,Grable, N.,Kung, P.P.,Sutton, S.,Maegley, K.A.,Yu, X.,Stewart, A.E.; Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.; Nat Commun, 7:11384-11384, 2016; PubMed: 27122193; DOI: 10.1038/ncomms11384

Experimental method

X-RAY DIFFRACTION (2.99 Å)