5IGL

Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine (BSP)

Summary for 5IGL

Entry DOI	10.2210/pdb5igl/pdb
Descriptor	Transcription initiation factor TFIID subunit 1-like, Bromosporine (3 entities in total)
Functional Keywords	transcription, taf1/tafii250, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q8IZX4
Total number of polymer chains	1
Total formula weight	18427.70
Authors	Filippakopoulos, P.,Picaud, S.,Felletar, I.,Krojer, T.,Tallant, C.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-02-28, release date: 2016-10-19, Last modification date: 2024-01-10)
Primary citation	Picaud, S.,Leonards, K.,Lambert, J.P.,Dovey, O.,Wells, C.,Fedorov, O.,Monteiro, O.,Fujisawa, T.,Wang, C.Y.,Lingard, H.,Tallant, C.,Nikbin, N.,Guetzoyan, L.,Ingham, R.,Ley, S.V.,Brennan, P.,Muller, S.,Samsonova, A.,Gingras, A.C.,Schwaller, J.,Vassiliou, G.,Knapp, S.,Filippakopoulos, P. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Sci Adv, 2:e1600760-e1600760, 2016 Cited by PubMed: 27757418 DOI: 10.1126/sciadv.1600760 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation