5IFU

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Glyburide

5IFU の概要

• エントリーDOI: 10.2210/pdb5ifu/pdb
• 関連するPDBエントリー: 4NCX 4Q15 4WI1
• 分子名称: Proline--tRNA ligase, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: plasmodium falciparum, prolyl-trna synthetase, prors, proline--trna ligase, glyburide, structural genomics, structural genomics consortium, sgc, ligase
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• 細胞内の位置: Cytoplasm : Q8I5R7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119764.94

構造登録者

Dranow, D.M.,Hewitt, S.N.,Abendroth, J.,Structural Genomics Consortium (SGC) (登録日: 2016-02-26, 公開日: 2016-11-16, 最終更新日: 2023-09-27)

• 主引用文献: Hewitt, S.N.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C.; Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.; ACS Infect Dis, 3:34-44, 2017; PubMed: 27798837; DOI: 10.1021/acsinfecdis.6b00078

実験手法

X-RAY DIFFRACTION (2.45 Å)