5ICN

HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4

Summary for 5ICN

DescriptorMetastasis-associated protein MTA1, Histone deacetylase 1, GLY-ALA-6A0-ARG-HIS, ... (6 entities in total)
Functional Keywordstranscription repression inositol phosphate corepressor histone deacetylase hdac1 hdac3 histones, transcription, metastasis associated protein, ip6
Biological sourceHomo sapiens (Human)
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Cellular locationIsoform Short: Cytoplasm. Isoform Long: Nucleus Q13330
Nucleus  Q13547
Total number of polymer chains3
Total molecular weight67157.56
Authors
Millard, C.J.,Robertson, N.S.,Watson, P.J.,Jameson, A.G.,Schwabe, J.W.R. (deposition date: 2016-02-23, release date: 2016-05-11, Last modification date: 2018-01-24)
Primary citation
Watson, P.J.,Millard, C.J.,Riley, A.M.,Robertson, N.S.,Wright, L.C.,Godage, H.Y.,Cowley, S.M.,Jamieson, A.G.,Potter, B.V.,Schwabe, J.W.
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.
Nat Commun, 7:11262-11262, 2016
PubMed: 27109927 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms11262
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.30260.2%5.1%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution