5ICN

HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4

Summary for 5ICN

Entry DOI	10.2210/pdb5icn/pdb
Descriptor	Metastasis-associated protein MTA1, Histone deacetylase 1, GLY-ALA-6A0-ARG-HIS, ... (6 entities in total)
Functional Keywords	transcription repression inositol phosphate corepressor histone deacetylase hdac1 hdac3 histones, transcription, metastasis associated protein, ip6
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	67157.56
Authors	Millard, C.J.,Robertson, N.S.,Watson, P.J.,Jameson, A.G.,Schwabe, J.W.R. (deposition date: 2016-02-23, release date: 2016-05-11, Last modification date: 2024-01-10)
Primary citation	Watson, P.J.,Millard, C.J.,Riley, A.M.,Robertson, N.S.,Wright, L.C.,Godage, H.Y.,Cowley, S.M.,Jamieson, A.G.,Potter, B.V.,Schwabe, J.W. Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. Nat Commun, 7:11262-11262, 2016 Cited by PubMed: 27109927 DOI: 10.1038/ncomms11262 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation