5I95

Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid

Summary for 5I95

Related5I96
DescriptorIsocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION, ... (7 entities in total)
Functional Keywordsidh, icd-m, idp nadp(+)-specific icdh oxalosuccinate decarboxylase, akg, alphakg, oxo-glutarate., oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationMitochondrion P48735
Total number of polymer chains1
Total molecular weight49489.87
Authors
Zhang, B.,Jin, L.,Wu, W.,Jiang, F.,DeLaBarre, B.,Travins, J.A.,Padyana, A.K. (deposition date: 2016-02-19, release date: 2017-03-01, Last modification date: 2017-07-05)
Primary citation
Yen, K.,Travins, J.,Wang, F.,David, M.D.,Artin, E.,Straley, K.,Padyana, A.,Gross, S.,DeLaBarre, B.,Tobin, E.,Chen, Y.,Nagaraja, R.,Choe, S.,Jin, L.,Konteatis, Z.,Cianchetta, G.,Saunders, J.O.,Salituro, F.G.,Quivoron, C.,Opolon, P.,Bawa, O.,Saada, V.,Paci, A.,Broutin, S.,Bernard, O.A.,de Botton, S.,Marteyn, B.S.,Pilichowska, M.,Xu, Y.,Fang, C.,Jiang, F.,Wei, W.,Jin, S.,Silverman, L.,Liu, W.,Yang, H.,Dang, L.,Dorsch, M.,Penard-Lacronique, V.,Biller, S.A.,Su, S.M.
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.
Cancer Discov, 7:478-493, 2017
PubMed: 28193778 (PDB entries with the same primary citation)
DOI: 10.1158/2159-8290.CD-16-1034
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.54 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.185401.1%0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5i95.pdb1.gz [168.26 KB])