5HT6

Crystal structure of the SET domain of the human MLL5 methyltransferase

Summary for 5HT6

• Entry DOI: 10.2210/pdb5ht6/pdb
• Descriptor: Histone-lysine N-methyltransferase 2E (2 entities in total)
• Functional Keywords: set domain, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus speckle . Isoform NKp44L: Cytoplasm : Q8IZD2
• Total number of polymer chains: 2
• Total formula weight: 32214.98

Authors

le Maire, A.,Mas-y-Mas, S.,Dumas, C.,Lebedev, A. (deposition date: 2016-01-26, release date: 2016-11-16)

• Primary citation: Mas-Y-Mas, S.,Barbon, M.,Teyssier, C.,Demene, H.,Carvalho, J.E.,Bird, L.E.,Lebedev, A.,Fattori, J.,Schubert, M.,Dumas, C.,Bourguet, W.,le Maire, A.; The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.; Plos One, 11:e0165139-e0165139, 2016; PubMed: 27812132; DOI: 10.1371/journal.pone.0165139

Experimental method

X-RAY DIFFRACTION (2.093 Å)