5HS1

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed with Voriconazole

5HS1 の概要

• エントリーDOI: 10.2210/pdb5hs1/pdb
• 関連するPDBエントリー: 4WMZ 5HQZ
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole, ... (4 entities in total)
• 機能のキーワード: voriconazole, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, resistance mutation, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61553.53

構造登録者

Sabherwal, M.,Sagatova, A.,Keniya, M.V.,Wilson, R.K.,Tyndall, J.D.A.,Monk, B.C. (登録日: 2016-01-24, 公開日: 2016-06-01, 最終更新日: 2023-09-27)

• 主引用文献: Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.,Monk, B.C.; Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.; Sci Rep, 6:26213-26213, 2016; PubMed: 27188873; DOI: 10.1038/srep26213

実験手法

X-RAY DIFFRACTION (2.1 Å)