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5HI4

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Summary for 5HI4
Entry DOI10.2210/pdb5hi4/pdb
Related5HHV 5HHX 5HI3 5HI5
DescriptorInterleukin-17A, CAT-2000 FAB heavy chain, CAT-2000 FAB light chain, ... (6 entities in total)
Functional Keywordsil-17a, psoriasis, md simulation, sulfonyl fluoride, inhibitor, macrocycle, immune system-inhibitor complex, immune system/inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationSecreted: Q16552
Total number of polymer chains7
Total formula weight128945.06
Authors
Liu, S. (deposition date: 2016-01-11, release date: 2016-08-31, Last modification date: 2023-09-27)
Primary citationLiu, S.,Dakin, L.A.,Xing, L.,Withka, J.M.,Sahasrabudhe, P.V.,Li, W.,Banker, M.E.,Balbo, P.,Shanker, S.,Chrunyk, B.A.,Guo, Z.,Chen, J.M.,Young, J.A.,Bai, G.,Starr, J.T.,Wright, S.W.,Bussenius, J.,Tan, S.,Gopalsamy, A.,Lefker, B.A.,Vincent, F.,Jones, L.H.,Xu, H.,Hoth, L.R.,Geoghegan, K.F.,Qiu, X.,Bunnage, M.E.,Thorarensen, A.
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep, 6:30859-30859, 2016
Cited by
PubMed: 27527709
DOI: 10.1038/srep30859
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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