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5GWK

Human topoisomerase IIalpha in complex with DNA and etoposide

Summary for 5GWK
Entry DOI10.2210/pdb5gwk/pdb
Related3QX3 5GWI 5GWJ
DescriptorDNA topoisomerase 2-alpha, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (5 entities in total)
Functional Keywordstype ii topoisomerase, anti-cancer drug, topoii cleavage complex, isomerase-dna-isomerase inhibitor complex, isomerase/dna/isomerase inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm : P11388
Total number of polymer chains6
Total formula weight199340.44
Authors
Wang, Y.R.,Wu, C.C.,Chan, N.L. (deposition date: 2016-09-12, release date: 2017-08-23, Last modification date: 2023-11-08)
Primary citationWang, Y.R.,Chen, S.F.,Wu, C.C.,Liao, Y.W.,Lin, T.S.,Liu, K.T.,Chen, Y.S.,Li, T.K.,Chien, T.C.,Chan, N.L.
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45:10861-10871, 2017
Cited by
PubMed: 28977631
DOI: 10.1093/nar/gkx742
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.152 Å)
Structure validation

217705

数据于2024-03-27公开中

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