5G48
H.pylori Beta clamp in complex with Diflunisal
Summary for 5G48
| Entry DOI | 10.2210/pdb5g48/pdb |
| Descriptor | DNA POLYMERASE III SUBUNIT BETA, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID (3 entities in total) |
| Functional Keywords | transferase, dna sliding clamp, processivity promoting factor |
| Biological source | HELICOBACTER PYLORI |
| Cellular location | Cytoplasm : O25242 |
| Total number of polymer chains | 2 |
| Total formula weight | 84977.28 |
| Authors | Pandey, P.,Gourinath, S. (deposition date: 2016-05-06, release date: 2017-06-21, Last modification date: 2024-01-10) |
| Primary citation | Pandey, P.,Verma, V.,Gautam, G.,Kumari, N.,Dhar, S.K.,Gourinath, S. Targeting the beta-clamp in Helicobacter pylori with FDA-approved drugs reveals micromolar inhibition by diflunisal. FEBS Lett., 591:2311-2322, 2017 Cited by PubMed: 28656718DOI: 10.1002/1873-3468.12734 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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