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5FVO

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-(3-methoxypropylamino)pyridin-3-yl)ethyl)-4- methylpyridin-2-amine

Summary for 5FVO
Entry DOI10.2210/pdb5fvo/pdb
Related5FVP 5FVQ 5FVR 5FVS 5FVT 5FVU 5FVV 5FVW 5FVX 5FVY 5FVZ 5FW0
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywordsoxidoreductase, nitric oxide synthase, inhibitor complex
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains1
Total formula weight50036.07
Authors
Li, H.,Poulos, T.L. (deposition date: 2016-02-10, release date: 2016-04-20, Last modification date: 2016-06-08)
Primary citationWang, H.,Qin, Y.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59:4913-, 2016
Cited by
PubMed: 27050842
DOI: 10.1021/ACS.JMEDCHEM.6B00273
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.12 Å)
Structure validation

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