5FOA

Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4)

Summary for 5FOA

Entry DOI	10.2210/pdb5foa/pdb
Related	5FO7 5FO8 5FO9 5FOB
Descriptor	COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, CD55 (3 entities in total)
Functional Keywords	lipid binding, complement system, immune system, plasma protein, regulators of complement activity, decay-accelerating activity
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Secreted: P01024 P08174 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 3: Secreted . Isoform 4: Secreted . Isoform 5: Secreted . Isoform 6: Cell membrane ; Lipid-anchor, GPI-anchor . Isoform 7: Cell membrane ; Lipid-anchor, GPI-anchor : P01024
Total number of polymer chains	6
Total formula weight	393516.70
Authors	Forneris, F.,Wu, J.,Xue, X.,Gros, P. (deposition date: 2015-11-18, release date: 2016-04-06, Last modification date: 2024-01-10)
Primary citation	Forneris, F.,Wu, J.,Xue, X.,Ricklin, D.,Lin, Z.,Sfyroera, G.,Tzekou, A.,Volokhina, E.,Granneman, J.C.,Hauhart, R.,Bertram, P.,Liszewski, M.K.,Atkinson, J.P.,Lambris, J.D.,Gros, P. Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35:1133-, 2016 Cited by PubMed: 27013439 DOI: 10.15252/EMBJ.201593673 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.188 Å)

Structure validation