5FJ2
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-((4-CHLORO-3-((METHYLAMINO)METHYL) PHENOXY)METHYL)QUINOLIN-2-AMINE
Summary for 5FJ2
| Entry DOI | 10.2210/pdb5fj2/pdb |
| Related | 5FJ3 |
| Descriptor | NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
| Functional Keywords | oxidoreductase, nitric oxide synthase, inhibitor complex |
| Biological source | BOS TAURUS (CATTLE) |
| Cellular location | Cell membrane : P29473 |
| Total number of polymer chains | 2 |
| Total formula weight | 102310.88 |
| Authors | Li, H.,Poulos, T.L. (deposition date: 2015-10-06, release date: 2015-10-28, Last modification date: 2015-11-25) |
| Primary citation | Cinelli, M.A.,Li, H.,Pensa, A.V.,Kang, S.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58:8694-, 2015 Cited by PubMed: 26469213DOI: 10.1021/ACS.JMEDCHEM.5B01330 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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