5ETY

Crystal Structure of human Tankyrase-1 bound to K-756

Summary for 5ETY

Entry DOI	10.2210/pdb5ety/pdb
Descriptor	Tankyrase-1, ZINC ION, 3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-1,4-dihydroquinazolin-2-one, ... (4 entities in total)
Functional Keywords	tankyrase, inhibitor, non-competitive, wnt signal, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	119151.46
Authors	Takahashi, Y.,Miyagi, H.,Suzuki, M.,Saito, J. (deposition date: 2015-11-18, release date: 2016-06-22, Last modification date: 2024-03-20)
Primary citation	Okada-Iwasaki, R.,Takahashi, Y.,Watanabe, Y.,Ishida, H.,Saito, J.,Nakai, R.,Asai, A. The Discovery and Characterization of K-756, a Novel Wnt/ beta-Catenin Pathway Inhibitor Targeting Tankyrase Mol.Cancer Ther., 15:1525-1534, 2016 Cited by PubMed: 27196752 DOI: 10.1158/1535-7163.MCT-15-0938 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation