5ESJ
Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with fluconazole
Summary for 5ESJ
Entry DOI | 10.2210/pdb5esj/pdb |
Related | 5ESE 5ESF 5ESG 5ESH 5ESI 5ESK 5ESL 5ESM 5ESN |
Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total) |
Functional Keywords | cyp51, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
Total number of polymer chains | 1 |
Total formula weight | 62838.00 |
Authors | Sagatova, A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2015-11-16, release date: 2016-11-23, Last modification date: 2023-09-27) |
Primary citation | Sagatova, A.A.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C. Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase. Antimicrob.Agents Chemother., 62:-, 2018 Cited by PubMed: 29263059DOI: 10.1128/AAC.02242-17 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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