5ENE

Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with 5-Amino-2-benzyl-1,3-oxazole-4-carbonitrile (SGC - Diamond I04-1 fragment screening)

Summary for 5ENE

Entry DOI	10.2210/pdb5ene/pdb
Descriptor	PH-interacting protein, 5-azanyl-2-(phenylmethyl)-1,3-oxazole-4-carbonitrile (3 entities in total)
Functional Keywords	bromodomain, phip, crystallographic fragment screen, transcription, structural genomics, structural genomics consortium, sgc, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15793.87
Authors	Krojer, T.,Talon, R.,Collins, P.,Bradley, A.,Cox, O.,Amin, J.,Szykowska, A.,Burgess-Brown, N.,Spencer, J.,Brennan, P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,von Delft, F.,Structural Genomics Consortium (SGC) (deposition date: 2015-11-09, release date: 2016-04-27, Last modification date: 2024-01-10)
Primary citation	Cox, O.B.,Krojer, T.,Collins, P.,Monteiro, O.,Talon, R.,Bradley, A.,Fedorov, O.,Amin, J.,Marsden, B.D.,Spencer, J.,von Delft, F.,Brennan, P.E. A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7:2322-2330, 2016 Cited by PubMed: 29910922 DOI: 10.1039/c5sc03115j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation