5EDR

EGFR kinase (T790M/L858R) with inhibitor compound 27: ~{N}-(1~{H}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine

Summary for 5EDR

Entry DOI	10.2210/pdb5edr/pdb
Related	5EDP 5EDQ
Descriptor	Epidermal growth factor receptor, ~{N}-(1~{H}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine (3 entities in total)
Functional Keywords	protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37910.80
Authors	Eigenbrot, C.,Yu, C. (deposition date: 2015-10-21, release date: 2015-12-02, Last modification date: 2024-03-06)
Primary citation	Hanan, E.J.,Baumgardner, M.,Bryan, M.C.,Chen, Y.,Eigenbrot, C.,Fan, P.,Gu, X.H.,La, H.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Sideris, S.,Yen, I.,Yu, C.,Heffron, T.P. 4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase. Bioorg.Med.Chem.Lett., 26:534-539, 2016 Cited by PubMed: 26639762 DOI: 10.1016/j.bmcl.2015.11.078 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation