5DYZ
Crystal structure of Asp251Gly/Gln307His mutant of cytochrome P450 BM3 in complex with N-palmitoylglycine
Summary for 5DYZ
Entry DOI | 10.2210/pdb5dyz/pdb |
Descriptor | Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, N-PALMITOYLGLYCINE, ... (4 entities in total) |
Functional Keywords | cytochrome p450, random mutagenesis, drug metabolism, substrate, oxidoreductase |
Biological source | Bacillus megaterium |
Cellular location | Cytoplasm : P14779 |
Total number of polymer chains | 2 |
Total formula weight | 108728.61 |
Authors | Di Nardo, G.,Dell'Angelo, V.,Gilardi, G. (deposition date: 2015-09-25, release date: 2016-01-20, Last modification date: 2024-01-10) |
Primary citation | Di Nardo, G.,Dell'Angelo, V.,Catucci, G.,Sadeghi, S.J.,Gilardi, G. Subtle structural changes in the Asp251Gly/Gln307His P450 BM3 mutant responsible for new activity toward diclofenac, tolbutamide and ibuprofen. Arch.Biochem.Biophys., 602:106-115, 2016 Cited by PubMed: 26718083DOI: 10.1016/j.abb.2015.12.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.967 Å) |
Structure validation
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