5DYZ

Crystal structure of Asp251Gly/Gln307His mutant of cytochrome P450 BM3 in complex with N-palmitoylglycine

Summary for 5DYZ

Entry DOI	10.2210/pdb5dyz/pdb
Descriptor	Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, N-PALMITOYLGLYCINE, ... (4 entities in total)
Functional Keywords	cytochrome p450, random mutagenesis, drug metabolism, substrate, oxidoreductase
Biological source	Bacillus megaterium
Cellular location	Cytoplasm : P14779
Total number of polymer chains	2
Total formula weight	108728.61
Authors	Di Nardo, G.,Dell'Angelo, V.,Gilardi, G. (deposition date: 2015-09-25, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citation	Di Nardo, G.,Dell'Angelo, V.,Catucci, G.,Sadeghi, S.J.,Gilardi, G. Subtle structural changes in the Asp251Gly/Gln307His P450 BM3 mutant responsible for new activity toward diclofenac, tolbutamide and ibuprofen. Arch.Biochem.Biophys., 602:106-115, 2016 Cited by PubMed: 26718083 DOI: 10.1016/j.abb.2015.12.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.967 Å)

Structure validation