5DNN

Nucleosome core particle containing adducts of gold(I)-triethylphosphane and ruthenium(II)-toluene PTA complexes

Summary for 5DNN

• Entry DOI: 10.2210/pdb5dnn/pdb
• Related: 5DNM
• Descriptor: Histone H3.2, dichloro[(1,2,3,4,5,6-eta)-6-methylbenzene]1,3,5-triaza-7lambda~5~-phosphatricyclo[3.3.1.1~3,7~]dec-7-ylruthenium, Histone H4, ... (10 entities in total)
• Functional Keywords: nucleosome, gold antitumour compound, ruthenium antitumour compound, histone binding, structural protein-dna complex, structural protein/dna
• Biological source: Xenopus laevis (African clawed frog); More
• Cellular location: Nucleus: P84233 P62799 P02281
• Total number of polymer chains: 10
• Total formula weight: 199920.43

Authors

Adhireksan, Z.,Ma, Z.,Davey, C.A. (deposition date: 2015-09-10, release date: 2016-09-14, Last modification date: 2023-11-08)

• Primary citation: Adhireksan, Z.,Palermo, G.,Riedel, T.,Ma, Z.,Muhammad, R.,Rothlisberger, U.,Dyson, P.J.,Davey, C.A.; Allosteric cross-talk in chromatin can mediate drug-drug synergy; Nat Commun, 8:14860-14860, 2017; PubMed: 28358030; DOI: 10.1038/ncomms14860

Experimental method

X-RAY DIFFRACTION (2.8 Å)