5DN2

Human NRP2 b1 domain in complex with the peptide corresponding to the C-terminus of VEGF-A

Summary for 5DN2

Entry DOI	10.2210/pdb5dn2/pdb
Descriptor	Neuropilin-2, Vascular endothelial growth factor A, 1,4-DIETHYLENE DIOXIDE, ... (5 entities in total)
Functional Keywords	signaling protein, neuropilin-2, vegfa, angiogenesis, heparin, receptor
Biological source	Homo sapiens (Human) More
Cellular location	Membrane ; Single-pass type I membrane protein . Isoform s9: Secreted : O60462 Secreted : P15692
Total number of polymer chains	7
Total formula weight	81763.29
Authors	Tsai, Y.C.I.,Frankel, P.,Fotinou, C.,Rana, R.,Zachary, I.,Djordjevic, S. (deposition date: 2015-09-09, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citation	Tsai, Y.C.,Fotinou, C.,Rana, R.,Yelland, T.,Frankel, P.,Zachary, I.,Djordjevic, S. Structural studies of neuropilin-2 reveal a zinc ion binding site remote from the vascular endothelial growth factor binding pocket. Febs J., 283:1921-1934, 2016 Cited by PubMed: 26991001 DOI: 10.1111/febs.13711 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation