5DI7

Crystal Structure of the ER-alpha Ligand-binding Domain in complex with an methyl-substituted A-CD ring estrogen derivative (1S,3aR,5S,7aS)-5-(4-hydroxy-2-methylphenyl)-7a-methyloctahydro-1H-inden-1-ol

Summary for 5DI7

Entry DOI	10.2210/pdb5di7/pdb
Related	5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, (1S,3aR,5S,7aS)-5-(4-hydroxy-2-methylphenyl)-7a-methyloctahydro-1H-inden-1-ol, ... (4 entities in total)
Functional Keywords	nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	62453.70
Authors	Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Cavett, V.,Nowak, J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. (deposition date: 2015-08-31, release date: 2016-05-04, Last modification date: 2023-09-27)
Primary citation	Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Nowak, J.,Wright, N.J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12:864-864, 2016 Cited by PubMed: 27107013 DOI: 10.15252/msb.20156701 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.241 Å)

Structure validation