5DG9

CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dGMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION

Summary for 5DG9

• Entry DOI: 10.2210/pdb5dg9/pdb
• Related: 5DG7 5DG8 5DGA 5DGB
• Descriptor: DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total)
• Functional Keywords: dna polymerase, dna enzyme, dna damage, translesion dna synthesis, etheno dna adducts, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 55361.65

Authors

Patra, A.,Egli, M. (deposition date: 2015-08-27, release date: 2016-06-08, Last modification date: 2023-09-27)

• Primary citation: Patra, A.,Su, Y.,Zhang, Q.,Johnson, K.M.,Guengerich, F.P.,Egli, M.; Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.; J.Biol.Chem., 291:14134-14145, 2016; PubMed: 27226627; DOI: 10.1074/jbc.M116.732487

Experimental method

X-RAY DIFFRACTION (2.15 Å)