5CQG

Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532

Summary for 5CQG

Entry DOI	10.2210/pdb5cqg/pdb
Descriptor	Telomerase reverse transcriptase, 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid (3 entities in total)
Functional Keywords	telomerase reverse transcriptase fold tert bibr15312, telomerase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Tribolium castaneum (Red flour beetle)
Total number of polymer chains	2
Total formula weight	141840.17
Authors	Bryan, C.,Rice, C.,Hoffman, H.,Harkisheimer, M.,Sweeney, M.,Skordalakes, E. (deposition date: 2015-07-21, release date: 2015-09-09, Last modification date: 2023-09-27)
Primary citation	Bryan, C.,Rice, C.,Hoffman, H.,Harkisheimer, M.,Sweeney, M.,Skordalakes, E. Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure, 23:1934-1942, 2015 Cited by PubMed: 26365799 DOI: 10.1016/j.str.2015.08.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation