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5COJ

Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with native substrate 2-(4-methyl-1,3-thiazol-5-yl)ethanol.

Summary for 5COJ
Entry DOI10.2210/pdb5coj/pdb
Related5CGE 5CM5 5GCA
DescriptorHydroxyethylthiazole kinase, 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsbacterial thiamine biosynthesis, hydroxyethylthiazole kinase, transferase, 2-(4-methyl-1, 3-thiazol-5-yl)ethanol
Biological sourceStaphylococcus aureus
Total number of polymer chains6
Total formula weight179923.27
Authors
Drebes, J.,Kuenz, M.,Eberle, R.J.,Oberthuer, D.,Cang, H.,Wrenger, C.,Betzel, C. (deposition date: 2015-07-20, release date: 2016-03-23, Last modification date: 2019-07-17)
Primary citationDrebes, J.,Kunz, M.,Windshugel, B.,Kikhney, A.G.,Muller, I.B.,Eberle, R.J.,Oberthur, D.,Cang, H.,Svergun, D.I.,Perbandt, M.,Betzel, C.,Wrenger, C.
Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.
Sci Rep, 6:22871-22871, 2016
Cited by
PubMed: 26960569
DOI: 10.1038/srep22871
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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