5BT4

Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe

Summary for 5BT4

• Entry DOI: 10.2210/pdb5bt4/pdb
• Descriptor: Bromodomain-containing protein 4, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: chromatin and transcription regulator, acetylation, structural genomics, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 3
• Total formula weight: 46949.40

Authors

Tallant, C.,Hay, D.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Newman, J.A.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-06-02, release date: 2015-07-01)

• Primary citation: Tallant, C.,Hay, D.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Newman, J.A.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.; Crystal structure of BRD4 first bromodomain in complex with a 3,5-dimethylisoxazol ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)