5AVI

Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 4

Summary for 5AVI

Entry DOI	10.2210/pdb5avi/pdb
Descriptor	Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, tert-butyl 2-[[4-[ethanoyl(methyl)amino]phenoxy]methyl]-5-(trifluoromethyl)benzoate, ... (4 entities in total)
Functional Keywords	agonist, complex, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : Q13133 Q15788
Total number of polymer chains	4
Total formula weight	72191.96
Authors	Matsui, Y.,Hanzawa, H.,Tamaki, K. (deposition date: 2015-06-16, release date: 2015-08-26, Last modification date: 2023-11-08)
Primary citation	Matsui, Y.,Yamaguchi, T.,Yamazaki, T.,Yoshida, M.,Arai, M.,Terasaka, N.,Honzumi, S.,Wakabayashi, K.,Hayashi, S.,Nakai, D.,Hanzawa, H.,Tamaki, K. Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists Bioorg.Med.Chem.Lett., 25:3914-3920, 2015 Cited by PubMed: 26238323 DOI: 10.1016/J.BMCL.2015.07.047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation