5AEP

Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders

Summary for 5AEP

• Entry DOI: 10.2210/pdb5aep/pdb
• Descriptor: TYROSINE-PROTEIN KINASE JAK2, 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-pyrrole-2-carboxamide (3 entities in total)
• Functional Keywords: transferase, protein kinase, jak2, myeloproliferative disorders, tumour cell proliferation inhibition, anti-cancer agents
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 35549.78

Authors

Canevari, G.,Bertrand, J.,Brasca, M.G.,Nesi, M.,Amboldi, N.,Avanzi, N.,Bindi, S.,Casero, D.,Ciomei, M.,Colombo, N.,Cribioli, S.,Fachin, G.,Felder, E.R.,Galvani, A.,Isacchi, A.,Motto, I.,Panzeri, A.,Gnocchi, P.,Donati, D. (deposition date: 2015-01-08, release date: 2015-04-29, Last modification date: 2024-01-10)

• Primary citation: Brasca, M.G.,Gnocchi, P.,Nesi, M.,Amboldi, N.,Avanzi, N.,Bertrand, J.,Bindi, S.,Canevari, G.,Casero, D.,Ciomei, M.,Colombo, N.,Cribioli, S.,Fachin, G.,Felder, E.R.,Galvani, A.,Isacchi, A.,Motto, I.,Panzeri, A.,Donati, D.; Novel Pyrrole Carboxamide Inhibitors of Jak2 as Potential Treatment of Myeloproliferative Disorders.; Bioorg.Med.Chem., 23:2387-, 2015; PubMed: 25882525; DOI: 10.1016/J.BMC.2015.03.059

Experimental method

X-RAY DIFFRACTION (1.95 Å)