5A7B
Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211
Summary for 5A7B
Entry DOI | 10.2210/pdb5a7b/pdb |
Descriptor | CELLULAR TUMOR ANTIGEN P53, ZINC ION, 2-[[4-(diethylamino)piperidin-1-yl]methyl]-6-ethynyl-4-(3-phenoxyprop-1-ynyl)phenol, ... (4 entities in total) |
Functional Keywords | antitumor protein, cancer, tumor suppression, ethynyl, dna binding, cancer therapy, small molecule stabilizers, molecular chaperone |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 50025.55 |
Authors | Joerger, A.C. (deposition date: 2015-07-03, release date: 2015-09-30, Last modification date: 2024-01-10) |
Primary citation | Wilcken, R.,Zimmermann, M.O.,Bauer, M.R.,Rutherford, T.J.,Fersht, A.R.,Joerger, A.C.,Boeckler, F.M. Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere. Acs Chem.Biol., 10:2725-, 2015 Cited by PubMed: 26378745DOI: 10.1021/ACSCHEMBIO.5B00515 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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