5W4L
Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in complex with HIV-1 clade A/E gp120, the CD4 mimetic M48U1, and the antibody N5-i5.
Summary for 5W4L
Entry DOI | 10.2210/pdb5w4l/pdb |
Related | 4H8W 4JZW |
Related PRD ID | PRD_001094 |
Descriptor | clade A/E 93TH057 HIV-1 gp120 core, CD4 mimetic peptide M48U1, Antibody N5-i5 Fab heavy chain, ... (9 entities in total) |
Functional Keywords | hiv-1 gp120, clade a/e 93th057, viral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 12 |
Total formula weight | 285301.18 |
Authors | Tolbert, W.D.,Gohain, N.,Pazgier, M. (deposition date: 2017-06-12, release date: 2017-11-15, Last modification date: 2023-11-15) |
Primary citation | Tolbert, W.D.,Gohain, N.,Alsahafi, N.,Van, V.,Orlandi, C.,Ding, S.,Martin, L.,Finzi, A.,Lewis, G.K.,Ray, K.,Pazgier, M. Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region. Structure, 25:1719-1731.e4, 2017 Cited by PubMed: 29056481DOI: 10.1016/j.str.2017.09.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.92 Å) |
Structure validation
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