5W21
Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex
Summary for 5W21
Entry DOI | 10.2210/pdb5w21/pdb |
Descriptor | Klotho, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ... (6 entities in total) |
Functional Keywords | complex, ligand, receptor, co-receptor, hydrolase-protein binding complex, hydrolase/protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 165062.43 |
Authors | Mohammadi, M. (deposition date: 2017-06-05, release date: 2018-01-24, Last modification date: 2023-10-04) |
Primary citation | Chen, G.,Liu, Y.,Goetz, R.,Fu, L.,Jayaraman, S.,Hu, M.C.,Moe, O.W.,Liang, G.,Li, X.,Mohammadi, M. alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature, 553:461-466, 2018 Cited by PubMed: 29342138DOI: 10.1038/nature25451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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