5VGJ
Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90, bound to a scaffolded WITO V1V2 domain
Summary for 5VGJ
Entry DOI | 10.2210/pdb5vgj/pdb |
Related | 5EWI |
Descriptor | 1FD6-V1V2-WITO, VRC38.01 Fab Heavy Chain, VRC38.01 Fab Light Chain, ... (6 entities in total) |
Functional Keywords | fab, hiv-1, v1v2, env, antibody, envelope, neutralizing, immune system, wito, 1fd6, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 3 |
Total formula weight | 67638.83 |
Authors | Gorman, J.,Li, J.,Kwong, P.D. (deposition date: 2017-04-11, release date: 2017-05-31, Last modification date: 2023-10-04) |
Primary citation | Cale, E.M.,Gorman, J.,Radakovich, N.A.,Crooks, E.T.,Osawa, K.,Tong, T.,Li, J.,Nagarajan, R.,Ozorowski, G.,Ambrozak, D.R.,Asokan, M.,Bailer, R.T.,Bennici, A.K.,Chen, X.,Doria-Rose, N.A.,Druz, A.,Feng, Y.,Joyce, M.G.,Louder, M.K.,O'Dell, S.,Oliver, C.,Pancera, M.,Connors, M.,Hope, T.J.,Kepler, T.B.,Wyatt, R.T.,Ward, A.B.,Georgiev, I.S.,Kwong, P.D.,Mascola, J.R.,Binley, J.M. Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop. Immunity, 46:777-791.e10, 2017 Cited by PubMed: 28514685DOI: 10.1016/j.immuni.2017.04.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.456 Å) |
Structure validation
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