5UJT
Crystal structure of human HLA-DQ8 in complex with insulin mimotope binding in register 3
Summary for 5UJT
Entry DOI | 10.2210/pdb5ujt/pdb |
Descriptor | MHC class II antigen, MHC class II HLA-DQ-beta-1, insulin mimotope, ... (6 entities in total) |
Functional Keywords | insulin, type i diabetes, t cell, autoimmune disease, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 9 |
Total formula weight | 136189.88 |
Authors | |
Primary citation | Wang, Y.,Sosinowski, T.,Novikov, A.,Crawford, F.,Neau, D.B.,Yang, J.,Kwok, W.W.,Marrack, P.,Kappler, J.W.,Dai, S. C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes. Proc. Natl. Acad. Sci. U.S.A., 115:162-167, 2018 Cited by PubMed: 29255035DOI: 10.1073/pnas.1716527115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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