5UBX
Crystal structure of a mutant mIgG2b Fc heterodimer in complex with Protein A peptide analog Z34C
Summary for 5UBX
Entry DOI | 10.2210/pdb5ubx/pdb |
Descriptor | Ig gamma-2B chain C region, Peptide analog of B-domain from Protein A - Z34C, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | protein a, fc complex, b-domain, z-domain, immunoglobulin fold, immune system |
Biological source | Mus musculus (Mouse) More |
Cellular location | Isoform 1: Cell membrane ; Single-pass membrane protein . Isoform 2: Secreted: P01867 P01867 |
Total number of polymer chains | 3 |
Total formula weight | 59278.68 |
Authors | Armstrong, A.A.,Zwolak, A.,Gilliland, G.L. (deposition date: 2016-12-21, release date: 2017-09-20, Last modification date: 2023-10-04) |
Primary citation | Zwolak, A.,Armstrong, A.A.,Tam, S.H.,Pardinas, J.R.,Goulet, D.R.,Zheng, S.,Brosnan, K.,Emmell, E.,Luo, J.,Gilliland, G.L.,Chiu, M.L. Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding. MAbs, 9:1306-1316, 2017 Cited by PubMed: 28898162DOI: 10.1080/19420862.2017.1375639 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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