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5TKJ

Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519

Summary for 5TKJ
Entry DOI10.2210/pdb5tkj/pdb
Related5TKK
DescriptorvFP1.01 chimeric mouse antibody heavy chain, vFP1.01 chimeric mouse antibody light chain, HIV-1 fusion peptide residue 512-519, ... (5 entities in total)
Functional Keywordsneutralizing, antibody, fusion-peptide, complex, immune system
Biological sourceMus musculus
More
Total number of polymer chains12
Total formula weight195826.94
Authors
Xu, K.,Liu, K.,Kwong, P.D. (deposition date: 2016-10-06, release date: 2018-04-04, Last modification date: 2023-10-04)
Primary citationXu, K.,Acharya, P.,Kong, R.,Cheng, C.,Chuang, G.Y.,Liu, K.,Louder, M.K.,O'Dell, S.,Rawi, R.,Sastry, M.,Shen, C.H.,Zhang, B.,Zhou, T.,Asokan, M.,Bailer, R.T.,Chambers, M.,Chen, X.,Choi, C.W.,Dandey, V.P.,Doria-Rose, N.A.,Druz, A.,Eng, E.T.,Farney, S.K.,Foulds, K.E.,Geng, H.,Georgiev, I.S.,Gorman, J.,Hill, K.R.,Jafari, A.J.,Kwon, Y.D.,Lai, Y.T.,Lemmin, T.,McKee, K.,Ohr, T.Y.,Ou, L.,Peng, D.,Rowshan, A.P.,Sheng, Z.,Todd, J.P.,Tsybovsky, Y.,Viox, E.G.,Wang, Y.,Wei, H.,Yang, Y.,Zhou, A.F.,Chen, R.,Yang, L.,Scorpio, D.G.,McDermott, A.B.,Shapiro, L.,Carragher, B.,Potter, C.S.,Mascola, J.R.,Kwong, P.D.
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24:857-867, 2018
Cited by
PubMed: 29867235
DOI: 10.1038/s41591-018-0042-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.118 Å)
Structure validation

217705

數據於2024-03-27公開中

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