5O4G
HER2 in complex with Fab MF3958
Summary for 5O4G
Entry DOI | 10.2210/pdb5o4g/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-2, MF3958 FAB light chain, MF3958 FAB heavy chain, ... (6 entities in total) |
Functional Keywords | her2 ectodomain, complex, fab, transferase, oncoprotein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 118196.12 |
Authors | De Nardis, C.,Gros, P. (deposition date: 2017-05-29, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Geuijen, C.A.W.,De Nardis, C.,Maussang, D.,Rovers, E.,Gallenne, T.,Hendriks, L.J.A.,Visser, T.,Nijhuis, R.,Logtenberg, T.,de Kruif, J.,Gros, P.,Throsby, M. Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade. Cancer Cell, 33:922-936.e10, 2018 Cited by PubMed: 29763625DOI: 10.1016/j.ccell.2018.04.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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