5NH3
CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV
Summary for 5NH3
Entry DOI | 10.2210/pdb5nh3/pdb |
Descriptor | Activin receptor type-2A, anti-human ActRIIB mAb BYM338 Fv heavy-chain, anti-human ActRIIB mAb BYM338 Fv light-chain, ... (6 entities in total) |
Functional Keywords | other, epitope mapping, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 81322.89 |
Authors | Scheufler, C. (deposition date: 2017-03-21, release date: 2017-11-15, Last modification date: 2024-01-17) |
Primary citation | Morvan, F.,Rondeau, J.M.,Zou, C.,Minetti, G.,Scheufler, C.,Scharenberg, M.,Jacobi, C.,Brebbia, P.,Ritter, V.,Toussaint, G.,Koelbing, C.,Leber, X.,Schilb, A.,Witte, F.,Lehmann, S.,Koch, E.,Geisse, S.,Glass, D.J.,Lach-Trifilieff, E. Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114:12448-12453, 2017 Cited by PubMed: 29109273DOI: 10.1073/pnas.1707925114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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