5N7B
Understanding the singular conformational landscape of the Tn antigens: Sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody
Summary for 5N7B
Entry DOI | 10.2210/pdb5n7b/pdb |
Descriptor | Ig heavy chain V-III region J606,Ig lambda-1 chain V region S43, APD(CG6)RP(NH2) peptide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | immune system, antibodies, antigen tn |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 27084.80 |
Authors | Companon, I.,Martinez-Saez, N.,Castro-Lopez, J.,Jimenez-Barbero, J.,Bernardes, G.J.L.,Busto, J.H.,Avenoza, A.,Jimenez-Oses, G.,Hurtado-Guerrero, R.,Peregrina, J.M.,Corzana, F. (deposition date: 2017-02-20, release date: 2018-06-27, Last modification date: 2024-01-17) |
Primary citation | Companon, I.,Guerreiro, A.,Mangini, V.,Castro-Lopez, J.,Escudero-Casao, M.,Avenoza, A.,Busto, J.H.,Castillon, S.,Jimenez-Barbero, J.,Asensio, J.L.,Jimenez-Oses, G.,Boutureira, O.,Peregrina, J.M.,Hurtado-Guerrero, R.,Fiammengo, R.,Bernardes, G.J.L.,Corzana, F. Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage. J.Am.Chem.Soc., 141:4063-4072, 2019 Cited by PubMed: 30726084DOI: 10.1021/jacs.8b13503 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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