5LA4
Crystal structure of apo human proheparanase
Summary for 5LA4
Entry DOI | 10.2210/pdb5la4/pdb |
Descriptor | Heparanase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | hydrolase, heparanase, proenzyme, gh79 |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome membrane; Peripheral membrane protein: Q9Y251 |
Total number of polymer chains | 1 |
Total formula weight | 59431.75 |
Authors | Wu, L.,Jin, Y.,Davies, G.J. (deposition date: 2016-06-13, release date: 2017-05-31, Last modification date: 2024-01-10) |
Primary citation | Wu, L.,Jiang, J.,Jin, Y.,Kallemeijn, W.W.,Kuo, C.L.,Artola, M.,Dai, W.,van Elk, C.,van Eijk, M.,van der Marel, G.A.,Codee, J.D.C.,Florea, B.I.,Aerts, J.M.F.G.,Overkleeft, H.S.,Davies, G.J. Activity-based probes for functional interrogation of retaining beta-glucuronidases. Nat. Chem. Biol., 13:867-873, 2017 Cited by PubMed: 28581485DOI: 10.1038/nchembio.2395 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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