5L7D
Structure of human Smoothened in complex with cholesterol
Summary for 5L7D
Entry DOI | 10.2210/pdb5l7d/pdb |
Descriptor | Smoothened homolog,Soluble cytochrome b562,Smoothened homolog, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... (4 entities in total) |
Functional Keywords | g protein coupled receptor, morphogen signaling, hedgehog signaling, cholesterol, signaling protein, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 142442.99 |
Authors | Byrne, E.F.X.,Sircar, R.,Miller, P.S.,Hedger, G.,Luchetti, G.,Nachtergaele, S.,Tully, M.D.,Mydock-McGrane, L.,Covey, D.F.,Rambo, R.P.,Sansom, M.S.P.,Newstead, S.,Rohatgi, R.,Siebold, C. (deposition date: 2016-06-03, release date: 2016-07-20, Last modification date: 2024-01-10) |
Primary citation | Byrne, E.F.,Sircar, R.,Miller, P.S.,Hedger, G.,Luchetti, G.,Nachtergaele, S.,Tully, M.D.,Mydock-McGrane, L.,Covey, D.F.,Rambo, R.P.,Sansom, M.S.,Newstead, S.,Rohatgi, R.,Siebold, C. Structural basis of Smoothened regulation by its extracellular domains. Nature, 535:517-522, 2016 Cited by PubMed: 27437577DOI: 10.1038/nature18934 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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